Zonulin Test

Elevated fecal levels of ZFP have been associated with metabolic syndrome, obesity, and apparently healthy cigarette smokers. High serum levels of ZFP (antigen) are correlated with abnormal results of the Lactulose Mannitol test; the long-accepted standard for intestinal permeability, but to date no such correlation has been reported with fecal ZFP. Excessive intake of simple sugars, sodium, emulsifiers, microbial transglutaminase (food additive) and nano-particles may also be triggers for increased fecal ZFP and intestinal permeability. Possible interventions to restore the gastrointestinal mucosal barrier include dietary changes, treatment of dysbiosis, digestive supports and anti-inflammatory supplements; specifically quercetin, vitamin C, curcumin, gamma-linoleic acid, omega-3 fatty acids (EPA, DHA), and aloe vera. Other nutrients such as zinc, beta-carotene, pantothenic acid, and L-glutamine may provide some support for rejuvenation of the mucosal barrier. The use of some probiotics has been shown to reduce serum and fecal zonulin levels, and inulin (about 10 grams per day) lowered serum zonulin after just five days in healthy young subjects. Consider a Comprehensive Stool Analysis to further investigate potential causes of increased intestinal permeability.

MosaicDX offers patient-friendly sample collection kits that make testing simple. Each kit includes:

• Visual, step-by-step instructions for test preparation and sample collection.
• Personalized shipping cards.
• Pediatric collection bags if needed.

Please Carefully Note Before Placing Your Lab Order

• All lab test sales are final. Once an order is placed, refunds, cancellations, exchanges, and chargebacks are not permitted, except where required by law.
• Cellular Advisory does not participate in, bill, accept assignment from, or coordinate with private insurance plans. We do not provide superbills and are unable to assist with insurance claims, reimbursement requests, or claim resolution related to laboratory testing, consultations, or related services.
• Lab kits cannot be shipped to P.O. boxes. Please provide a valid residential or business shipping address at checkout.
• After your lab test order is placed, you are responsible for carefully reviewing all instructions, completing any required sample collection or lab draw, and returning the specimen according to the laboratory’s requirements.
• All laboratory testing is performed by independent third-party laboratories, including but not limited to Mosaic Diagnostics and ZRT Laboratory, when applicable. Cellular Advisory does not operate these laboratories and is not responsible for laboratory processing times, rejected samples, delayed shipments, incomplete submissions, or laboratory-specific requirements.
• After your order is completed, you will receive follow-up instructions by email or through the applicable lab portal. Please review those instructions carefully before beginning your test.